Re: Founder is a histamine release ?

Posted by Bob Berentz on May 15, 2004 at 09:22:33:

In Reply to: Re: Founder is a histamine release ? posted by M. W. Myers, D.V.M. on September 15, 2003 at 20:14:43:

: : Okay .. thoughts please !
: : Horse found in beginning stages of founder,front legs out in front of him to releave preasure from them,
: : rear tucked a bit under to bring weight to back hooves.
: : Extreme fever in front feet,the horse wouldn't lift them without a huge fight.No vet would come out ( a ussual in my area),the only medicine on hand was bantamine but wouldn't arive for an hour.
: : This was my call and I'd like opinions please.I lifted hooves into ice water buckets and gave 8oz. benadryl(anti-histamine)to block swelling from histamine release.In 15 minutes hooves and above were cool.In 45 minutes hooves where still cool and horse had stopped heaving and sweating.All physical symptoms had stopped accept ofcoarse the sore hooves before bantamine arrived. The edss blue foam pads ( www.hopeforsoundness.com)were put on and treatment started after the bantamine had tacken affect ( this I KNOW is scientifically based and I have NO questions on EDSS).My question is,has anyone tried anti-histamine in this situation and did it /can it work like I think it did ?

: : Sincerely - Sharon Story

: Histamines play only a minor part in the inflammatory responses of the equine. Their reactions revolve mainly around prostaglandins which is why Banamine (flunixin) is the drug of choice even for shock in the equine (along with corticosteroids). Respiratory conditions like COPD appear to have the most histamine type reactions. Even COPD requires treatment with other medications than antihistamine. Only cromolyn sodium, a mast cell stabilizer, has any effect in some cases.

: The effect you saw may have occurred from the cool hoof bath alone, could have occurred with no treatment at all, or may have been due to a slight calming effect of the antihistamine.

: Antihistamines have fallen out of favor for use in the equine as they have generally proven ineffective and the side effects, either sedation or hyperexcitability, are undesirable.

: M. W. Myers, D.V.M.

I increased the grain to my pregnant mare who has a history of lamination/founder. She is in a bad way and a week away from foaling. I think antihistamine is right even thou the vet said no. A lot of times owners do things that work. What would you recommend at this point based on what you have learned?

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: : : Okay .. thoughts please ! : : : Horse found in beginning stages of founder,front legs out in front of him to releave preasure from them, : : : rear tucked a bit under to bring weight to back hooves. : : : Extreme fever in front feet,the horse wouldn't lift them without a huge fight.No vet would come out ( a ussual in my area),the only medicine on hand was bantamine but wouldn't arive for an hour. : : : This was my call and I'd like opinions please.I lifted hooves into ice water buckets and gave 8oz. benadryl(anti-histamine)to block swelling from histamine release.In 15 minutes hooves and above were cool.In 45 minutes hooves where still cool and horse had stopped heaving and sweating.All physical symptoms had stopped accept ofcoarse the sore hooves before bantamine arrived. The edss blue foam pads ( www.hopeforsoundness.com)were put on and treatment started after the bantamine had tacken affect ( this I KNOW is scientifically based and I have NO questions on EDSS).My question is,has anyone tried anti-histamine in this situation and did it /can it work like I think it did ? : : : Sincerely - Sharon Story : : Histamines play only a minor part in the inflammatory responses of the equine. Their reactions revolve mainly around prostaglandins which is why Banamine (flunixin) is the drug of choice even for shock in the equine (along with corticosteroids). Respiratory conditions like COPD appear to have the most histamine type reactions. Even COPD requires treatment with other medications than antihistamine. Only cromolyn sodium, a mast cell stabilizer, has any effect in some cases. : : The effect you saw may have occurred from the cool hoof bath alone, could have occurred with no treatment at all, or may have been due to a slight calming effect of the antihistamine. : : Antihistamines have fallen out of favor for use in the equine as they have generally proven ineffective and the side effects, either sedation or hyperexcitability, are undesirable. : : M. W. Myers, D.V.M. : I increased the grain to my pregnant mare who has a history of lamination/founder. She is in a bad way and a week away from foaling. I think antihistamine is right even thou the vet said no. A lot of times owners do things that work. What would you recommend at this point based on what you have learned?

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